Circulating exosomal lncRNAs in patients with chronic coronary syndromes.

ABSTRACT:

Introduction

The concept of chronic coronary syndrome (CCS) was first presented at the European Society of Cardiology Meeting in 2019. However, the roles of exosomal lncRNAs in CCS remain largely unclear.

Material and methods

A case-control study was performed with a total of 218 participants (137 males and 81 females), including 15 CCS patients and 15 controls for sequencing profiles, 20 CCS patients and 20 controls for the first validation, and 100 CCS patients and 48 controls for the second validation. Exosomes were isolated from the plasma of CCS patients and controls, and exosomal lncRNAs were identified by sequencing profiles and verified twice by qRT-PCR analysis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of

SUBMITTER: Zheng M 

PROVIDER: S-EPMC9897088 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature