Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model.

ABSTRACT: Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO₂) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO₂ as a model drug, and a sustained-ClO₂-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4-35 ℃ and release

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9897158 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature