Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC9897159 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Li Zhaolong Z Hao Pengfei P Zhao Zhilei Z Gao Wenying W Huan Chen C Li Letian L Chen Xiang X Wang Hong H Jin Ningyi N Luo Zhao-Qing ZQ Li Chang C Zhang Wenyan W
Signal transduction and targeted therapy 20230203 1
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; its structural protein envelope (E) is critical for viral entry, budding, production, and induction of pathology which makes it a potential target for therapeutics against COVID-19. Here, we find that the E3 ligase RNF5 interacts with and catalyzes ubiquitination of E on the 63rd lysine, leading to its degradation by the ubiquitin-prote ...[more]