Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.

ABSTRACT:

Background

The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and function. The Hippo signaling pathway is a molecular signaling pathway fundamental to heart development and regeneration. Although abnormalities of the Hippo pathway are associated with cardiac arrhythmias in human patients, the role of this pathway in the SAN is unknown.

Methods

We investigated key regulators of the Hippo pathway in SAN pacemaker cells by conditionally inactivating the Hippo signaling kinases Lats1 and Lats2 using the tamoxifen-inducible, cardiac conduction system-specific Cre driver Hcn4^Cr

SUBMITTER: Zheng M 

PROVIDER: S-EPMC9897204 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature