Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system.

ABSTRACT: Interspecies interactions can drive the emergence of unexpected microbial phenotypes that are not observed when studying monocultures. The cystic fibrosis (CF) lung consists of a complex environment where microbes, living as polymicrobial biofilm-like communities, are associated with negative clinical outcomes for persons with CF (pwCF). However, the current lack of in vitro models integrating the microbial diversity observed in the CF airway hampers our understanding of why polymicrobial communities are recalcitrant to therapy in this disease. Here, integrating computational approaches informed by clinical data, we built a mixed community of clinical relevance to the CF lung composed of Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus sanguinis, and Pre

SUBMITTER: Jean-Pierre F 

PROVIDER: S-EPMC9897730 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature