Buyang Huanwu decoction improves neural recovery after spinal cord injury in rats through the mTOR signaling pathway and autophagy.

ABSTRACT:

Background

Spinal cord injury (SCI) refers to the interruption of the tracts inside the spinal cord caused by various factors. The repair of damaged axons has always been a difficult point in clinical treatment and neuroscience research. The treatment of SCI with Buyang huanwu decoction (BYHWD), a well-known recipe for invigorating Qi (a vital force forming part of any living entity in traditional Chinese culture) and promoting blood circulation, shows a good effect.

Methods

The rubrospinal tract (RST) transection model in rats was established in this study and rats were administrated with low (BL), medium (BM), or high (BH) doses of BYHWD.

Results

Compared with the SCI group, BL, BM moderately, and BH significantly improved the motor function of forelimbs and increas

SUBMITTER: Nie Y 

PROVIDER: S-EPMC9897784 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature