6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson's Disease.

ABSTRACT:

Background

Gastrointestinal dysfunction is one of the most common non-motor symptoms in Parkinson's disease (PD). The exact mechanisms behind these symptoms are not clearly understood. Studies in the well-established 6-hydroxydopamine (6-OHDA) lesioned rats of PD have shown altered contractility in isolated circular and longitudinal smooth muscle strips of distal colon. Contractile changes in proximal colon and distal ileum are nevertheless poorly studied. Moreover, segments may serve as better tissue preparations to understand the interplay between circular and longitudinal smooth muscle. This study aimed to compare changes in contractility between isolated full-thickness distal colon muscle strips and segments, and extend the investigation to proximal colon and distal ileum in th

SUBMITTER: Murillo MDP 

PROVIDER: S-EPMC9897937 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature