Dissecting the Domains of Parkinson's Disease: Insights from Longitudinal Item Response Theory Modeling.

ABSTRACT:

Background

Longitudinal item response theory (IRT) models previously suggested that the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor examination has two salient domains, tremor and nontremor, that progress in time and in response to treatment differently.

Objective

Apply longitudinal IRT modeling, separating tremor and nontremor domains, to reanalyze outcomes in the previously published clinical trial (Study of Urate Elevation in Parkinson's Disease, Phase 3) that showed no overall treatment effects.

Methods

We applied unidimensional and multidimensional longitudinal IRT models to MDS-UPDRS motor examination items in 298 participants with Parkinson's disease from the Study of Urate Elevation in Parkinson's Disease, Phase 3 (plac

SUBMITTER: Luo S 

PROVIDER: S-EPMC9897939 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature