Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research.
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ABSTRACT:
SUBMITTER: Yuan M
PROVIDER: S-EPMC9898044 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research.
Yuan Minghao M Wang Yangyang Y Huang Zhenting Z Jing Feng F Qiao Peifeng P Zou Qian Q Li Jing J Cai Zhiyou Z
Journal of biomedical research 20220901 1
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The major pathological changes in AD progression are the generation and accumulation of amyloid-beta (Aβ) peptides as well as the presence of abnormally hyperphosphorylated tau proteins in the brain. Autophagy is a conserved degradation pathway that eliminates abnormal protein aggregates and damaged organelles. Previous studies have suggested that autophagy plays a key role in the production and clearance of Aβ peptides t ...[more]
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