Ontology highlight
ABSTRACT:
SUBMITTER: Gangwani MR
PROVIDER: S-EPMC9898160 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Gangwani Mohitkumar R MR Soto Joselyn S JS Jami-Alahmadi Yasaman Y Tiwari Srushti S Kawaguchi Riki R Wohlschlegel James A JA Khakh Baljit S BS
Cell reports 20230107 1
Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts, including in striatal neurons and astrocytes. It is unknown whether pathophysiology in vivo can be attenuated by lowering mHTT in either cell type throughout the brain, and the relative contributions of neurons and astrocytes to HD remain undefined. We use zinc finger protein (ZFP) transcriptional repressors to cell-sel ...[more]