Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.

ABSTRACT:

Background

Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these loci are in noncoding regions and are predicted to regulate gene expression. Given that vascular smooth muscle cells (SMCs) play critical roles in the development and progression of CAD, we aimed to identify the subset of the CAD loci associated with the regulation of transcription in distinct SMC phenotypes.

Methods

We measured gene expression in SMCs isolated from the ascending aortas of 151 heart transplant donors of various genetic ancestries in quiescent or proliferative conditions and calculated the association of their expression and splicing with ~6.3 million

SUBMITTER: Aherrahrou R 

PROVIDER: S-EPMC9898186 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature