Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC9898190 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Yu Jingfang J Vogt Merly C MC Fox Bennett W BW Wrobel Chester J J CJJ Fajardo Palomino Diana D Curtis Brian J BJ Zhang Bingsen B Le Henry H HH Tauffenberger Arnaud A Hobert Oliver O Schroeder Frank C FC
Nature chemical biology 20221010 2
The neurotransmitter serotonin plays a central role in animal behavior and physiology, and many of its functions are regulated via evolutionarily conserved biosynthesis and degradation pathways. Here we show that in Caenorhabditis elegans, serotonin is abundantly produced in nonneuronal tissues via phenylalanine hydroxylase, in addition to canonical biosynthesis via tryptophan hydroxylase in neurons. Combining CRISPR-Cas9 genome editing, comparative metabolomics and synthesis, we demonstrate tha ...[more]