Ca_V3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum.

ABSTRACT: The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic currents to its cognitive function is not well studied. Although we recently reported that low-voltage-activated T-type calcium channels (T-channels) are crucial for the burst firing pattern regulation in the dSub pyramidal neurons, their potential role in learning and memory remains unclear. Here we used in vivo local field potential recordings and miniscope calcium imaging in freely behaving mice coupled with pharmacological and genetic tools to address this gap in knowledge. We show that the Ca_V3.1 isoform of T-channels is critically involved in controlling neuronal activity in the dSub in vivo. Altering neuronal excitabi

SUBMITTER: Joksimovic SM 

PROVIDER: S-EPMC9898223 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature