Immature and mature bone marrow-derived dendritic cells exhibit distinct intracellular mechanical properties.

ABSTRACT: Dendritic cells (DCs) patrol the organism at an immature stage to detect the presence of pathogens. Once activated, these mature DCs reach the lymph nodes to activate antigen-specific T lymphocytes and thus initiate an adaptative immune response to control the pathogen. The migration of both immature and mature DCs is a key process for their optimal function. DC migration requires transit through narrow constrictions that is allowed by their high local and global deformation capabilities. In addition to cytoplasmic changes, the nucleus mechanical properties also have a major impact for cellular migration and motility. Yet, nucleus intracellular mobility of dendritic cells or its variation upon maturation have not been investigated. Our study defines the biophysical phenotypic variations of

SUBMITTER: Leblanc-Hotte A 

PROVIDER: S-EPMC9898242 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature