Association of time spent in outdoor light and genetic risk with the incidence of depression.

ABSTRACT: Depression is the consequence of both environment and genes working together. Genetic factors increase depression risk, but it is unclear whether this association can be offset by time spent in outdoor light. The study was undertaken to investigate the optimal time spent in outdoor light for lowering the risk of depression and the joint association of time spent in outdoor light and depression genetic risk. In UK Biobank, 380,976 depression-free individuals were included in this study. Polygenic risk score (PRS) was categorized into three groups in terms of tertiles. Time spent in outdoor light on a typical day in summer or winter originated from the questionnaire survey. Depression was defined as hospital admission. The potential dose-response relationship between time spent in outdoor li

SUBMITTER: Lin J 

PROVIDER: S-EPMC9898270 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature