Docosahexaenoic acid improves cognition and hippocampal pyroptosis in rats with intrauterine growth restriction.

ABSTRACT:

Background and objective

Intrauterine growth restriction (IUGR) is defined as the failure of a fetus to reach its genetic growth potential in utero resulted by maternal, placental, fetal, and genetic factors. Previous studies have reported that IUGR is associated with a high incidence of neurological damage, although the precise causes of such damage remain unclear. We aimed to investigate whether cognitive impairment in rats with IUGR is related to pyroptosis of hippocampal neurons and determine the effect of early intervention with docosahexaenoic acid (DHA).

Methods

Learning and memory function was assessed using the Morris water maze test. The morphological structure and ultrastructure of the hippocampus was examined via hematoxylin and eosin staining and electron micros

SUBMITTER: Wan L 

PROVIDER: S-EPMC9898307 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature