Atypical cortical processing of bottom-up speech binding cues in children with autism spectrum disorders.

ABSTRACT: Individuals with autism spectrum disorder (ASD) commonly display speech processing abnormalities. Binding of acoustic features of speech distributed across different frequencies into coherent speech objects is fundamental in speech perception. Here, we tested the hypothesis that the cortical processing of bottom-up acoustic cues for speech binding may be anomalous in ASD. We recorded magnetoencephalography while ASD children (ages 7-17) and typically developing peers heard sentences of sine-wave speech (SWS) and modulated SWS (MSS) where binding cues were restored through increased temporal coherence of the acoustic components and the introduction of harmonicity. The ASD group showed increased long-range feedforward functional connectivity from left auditory to parietal cortex with concurr

SUBMITTER: Alho J 

PROVIDER: S-EPMC9898310 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature