Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies.

ABSTRACT:

Purpose

The aim of this systematic review was to determine if adipose tissue-derived cell-based injectable therapies can induce disease-modifying effects in joints affected by osteoarthritis (OA).

Methods

A systematic review was performed on three electronic databases (PubMed, Web of Science, Embase) according to PRISMA guidelines. A synthesis of the results was performed investigating disease-modifying effects in preclinical studies comparing injectable adipose-derived products with OA controls or other products, different formulations or injection intervals, and the combination with other products. The risk of bias was assessed according to the SYRCLE's tool.

Results

Seventy-one studies were included (2,086 animals) with an increasing publication trend over time. Ex

SUBMITTER: Perucca Orfei C 

PROVIDER: S-EPMC9898370 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature