An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation.

ABSTRACT: Although hydrogels have been widely studied because of their satisfactory biocompatibility and plasticity, their application is limited in bone tissue engineering (BTE) owing to their inadequate mechanical properties and absence of osteogenic activity. To address this issue, we developed an updated alendronate (ALN)-Ca²⁺/Mg²⁺-doped supramolecular (CMS) hydrogel based on our previously developed mechanically resilient "host-guest macromer" (HGM) hydrogel to improve the hydrogel's mechanical properties and osteogenic activity. The CMS hydrogel was prepared by introducing a new physical crosslinking comprising the strong chelation of the comonomer acrylate alendronate (Ac-ALN) and Ca²⁺/Mg²⁺ in the HGM hydrogel. Compared with the previously developed

SUBMITTER: Yu T 

PROVIDER: S-EPMC9898439 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature