Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women.

ABSTRACT:

Background

Vulnerability theories propose that suboptimal levels of lipid markers and proinflammatory proteins predict future heightened depression. Scar models posit the reverse association. However, most studies that tested relationships between non-specific immune/endocrine markers and depression did not separate temporal inferences between people and within-person and how different immunometabolism markers related to unique depression symptoms. We thus used cross-lagged prospective network analyses (CLPN) to investigate this topic.

Methods

Community midlife women (n = 2224) completed the Center for Epidemiologic Studies-Depression scale and provided biomarker samples across five time-points spanning 9 years. CLPN identified significant relations (edges) amo

SUBMITTER: Zainal NH 

PROVIDER: S-EPMC9898473 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature