Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress.

ABSTRACT: Tryptophan and its derived metabolites have been assumed to play important roles in the development and survival of organisms. However, the links of tryptophan and its derived metabolites to temperature change remained largely cryptic. Here we presented that a class of prenyl indole alkaloids biosynthesized from tryptophan dramatically accumulated in thermophilic fungus Thermomyces dupontii under cold stress, in which lipid droplets were also highly accumulated and whose conidiophores were highly build-up. Concurrently, disruption of the key NRPS gene involved in the biosynthesis of prenyl indole alkaloids, resulted in decreased lipid and shrunken mitochondria but enlarged vacuoles. Moreover, the Fe³⁺ and superoxide levels in ΔNRPS were significantly increas

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9898655 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature