A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.

ABSTRACT: Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and exposed to infectious injury, we characterized the phenotypic and molecular adaptations to a 12-month exercise across 14 tissues/organs at single-cell resolution. Overall, exercise protects tissues from infectious injury, although more effectively in young animals, and benefits aged individuals in terms of inflammaging suppression and tissue rejuvenation, with structural improvement in the central nervous system and systemic vasculature being the most prominent. In vascular endothelial cells, we found that readjusting the rhythmic machinery via the core circadian clock protein BMAL1 delayed senescence and facil

SUBMITTER: Sun S 

PROVIDER: S-EPMC9898793 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature