C. elegans Gene Regulatory Alleles and Reporter Bashing Studies.
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ABSTRACT:
SUBMITTER: Froehlich JJ
PROVIDER: S-EPMC9898812 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
<i>C. elegans</i> Gene Regulatory Alleles and Reporter Bashing Studies.
Froehlich Jonathan J JJ Rajewsky Nikolaus N
microPublication biology 20230120
Gene regulation has been studied in <i>C. elegans</i> for over 30 years. In this analysis of 102 publications, we find that most transcriptional cis-regulatory elements are located within 5,000 bp of the transcription start site. Over 75% of studies conclude that transcriptional elements and 5'UTRs activate-, while 3'UTRs repress gene expression. While gene regulatory mutations make up less than 0.8% of alleles in forward genetics screens, recent CRISPR-Cas approaches are increasing the number o ...[more]
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