Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

ABSTRACT:

Importance

The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is hypoactive sexual desire disorder (HSDD), which affects 8% of men but currently has no effective pharmacological treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing to emerging understanding of its role in reproductive behavior.

Objective

To determine the physiological, behavioral, neural, and hormonal effects of kisspeptin administration in men with HSDD.

Design, setting, and participants

This double-blind, 2-way crossover, placebo-controlled randomized clinical trial was performed

SUBMITTER: Mills EG 

PROVIDER: S-EPMC9898824 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature