High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study.

ABSTRACT:

Background

Drug-induced prolongation of the corrected QT interval (QTc) increases the risk for Torsades de Pointes (TdP) and sudden cardiac death. Medication effects on the QTc have been studied in controlled settings but may not be well evaluated in real-world settings where medication effects may be modulated by patient demographics and comorbidities as well as the usage of other concomitant medications.

Objective

We demonstrate a new, high-throughput method leveraging electronic health records (EHRs) and the Surescripts pharmacy database to monitor real-world QTc-prolonging medication and potential interacting effects from demographics and comorbidities.

Methods

We included all outpatient electrocardiograms (ECGs) from September 2008 to December 2019 at a large aca

SUBMITTER: Yuan N 

PROVIDER: S-EPMC9898836 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature