Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.

ABSTRACT:

Background

In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn leads to severe and potentially fatal organ damage. However, IgLCs can also be highly soluble and non-toxic. It is generally thought that the cause for this differential solubility behaviour is solely found within the IgLC amino acid sequences, and a variety of individual sequence-related biophysical properties (e.g. thermal stability, dimerisation) have been proposed in different studies as major determinants of the aggregation in vivo. Here, we investigate biophysical properties underlying IgLC amyloidogenicity.

Results

We

SUBMITTER: Sternke-Hoffmann R 

PROVIDER: S-EPMC9898917 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature