Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.

ABSTRACT:

Purpose

The 5-year survival rate of children with acute lymphoblastic leukemia (ALL) is 85-90%, with a 10-15% rate of treatment failure. Next-generation sequencing (NGS) identified recurrent mutated genes in ALL that might alter the diagnosis, classification, prognostic stratification, treatment, and response to ALL. Few studies on gene mutations in Chinese pediatric ALL have been identified. Thus, an in-depth understanding of the biological characteristics of these patients is essential. The present study aimed to characterize the spectrum and clinical features of recurrent driver gene mutations in a single-center cohort of Chinese pediatric ALL.

Methods

We enrolled 219 patients with pediatric ALL in our single center. Targeted sequencing based on NGS was used to detect gen

SUBMITTER: Shen D 

PROVIDER: S-EPMC9898934 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature