Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data.

ABSTRACT:

Background

In malaria endemic regions, transmission of Plasmodium falciparum parasites is often seasonal with very low transmission during the dry season and high transmission in the wet season. Parasites survive the dry season within some individuals who experience prolonged carriage of parasites and are thought to 'seed' infection in the next transmission season.

Methods

Dry season carriers and their role in the subsequent transmission season are characterized using a combination of mathematical simulations and data analysis of previously described data from a longitudinal study in Mali of individuals aged 3 months-12 years (n = 579).

Results

Simulating the life-history of individuals experiencing repeated exposure to infection predicts that dry season carriage is m

SUBMITTER: Stadler E 

PROVIDER: S-EPMC9898990 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature