<i>MUC5B</i>, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study.

ABSTRACT:

Background

The MUC5B promoter variant (rs35705950) and telomere length are linked to pulmonary fibrosis and CT-based qualitative assessments of interstitial abnormalities, but their associations with longitudinal quantitative changes of the lung interstitium among community-dwelling adults are unknown.

Methods

We used data from participants in the Multi-Ethnic Study of Atherosclerosis with high-attenuation areas (HAAs, Examinations 1-6 (2000-2018)) and MUC5B genotype (n=4552) and telomere length (n=4488) assessments. HAA was defined as the per cent of imaged lung with attenuation of -600 to -250 Hounsfield units. We used linear mixed-effects models to examine associations of MUC5B risk allele (T) and telomere length with longitudinal changes in HAAs. Joi

SUBMITTER: Kim JS 

PROVIDER: S-EPMC9899287 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature