Dissociation of Broca's area from Broca's aphasia in patients undergoing neurosurgical resections.

ABSTRACT:

Objective

Broca's aphasia is a syndrome of impaired fluency with retained comprehension. The authors used an unbiased algorithm to examine which neuroanatomical areas are most likely to result in Broca's aphasia following surgical lesions.

Methods

Patients were prospectively evaluated with standardized language batteries before and after surgery. Broca's area was defined anatomically as the pars opercularis and triangularis of the inferior frontal gyrus. Broca's aphasia was defined by the Western Aphasia Battery language assessment. Resections were outlined from MRI scans to construct 3D volumes of interest. These were aligned using a nonlinear transformation to Montreal Neurological Institute brain space. A voxel-based lesion-symptom mapping (VLSM) algorithm was used to tes

SUBMITTER: Andrews JP 

PROVIDER: S-EPMC9899289 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature