MUC1 promotes lung metastases of liver cancer by impairing anti-tumor immunity.

ABSTRACT:

Purpose

MUC1 is a membrane bound protein that can regulate tumor progression but its role in tumor metastasis and the metastatic microenvironment remains unclear.

Methods

We performed differential gene analysis for primary liver cancer (n = 31) and lung metastases (n = 31) using the Gene Expression Omnibus (GEO) dataset (GSE141016) and obtained RNA sequencing data from 374 liver cancer and 50 normal tissues from The Cancer Genome Atlas (TCGA). We analyzed the prognostic value of MUC1 and the relationship between MUC1 and the TME using online databases and a clinical cohort. Immunohistochemistry detected MUC1 in normal liver, liver cancer, and lung metastases. Multiplex immunohistochemistry staining detected immune cells in the metastatic microenvironment.

Results

High

SUBMITTER: Yin Y 

PROVIDER: S-EPMC9899301 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature