Association of postnatal severe acute malnutrition with pancreatic exocrine and endocrine function in children and adults: a systematic review.

ABSTRACT: Severe acute malnutrition may lead both concurrently and subsequently to malabsorption and impaired glucose metabolism from pancreatic dysfunction. We conducted a systematic review to investigate the associations of current and prior postnatal wasting malnutrition with pancreatic endocrine and exocrine functions in humans. We searched PubMed, Google Scholar, Web of Science and reference lists of retrieved articles, limited to articles in English published before 1 February 2022. We included sixty-eight articles, mostly cross-sectional or cohort studies from twenty-nine countries including 592 530 participants, of which 325 998 were from a single study. Many were small clinical studies from decades ago and rated poor quality. Exocrine pancreas function, indicated by duodenal fluid or serum

SUBMITTER: Ferdous F 

PROVIDER: S-EPMC9899575 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature