Inhaled Nitric Oxide vs Epoprostenol During Acute Respiratory Failure: An Observational Target Trial Emulation.

ABSTRACT:

Background

The inhaled vasodilators nitric oxide and epoprostenol may be initiated to improve oxygenation in mechanically ventilated patients with severe acute respiratory failure (ARF); however, practice patterns and head-to-head comparisons of effectiveness are unclear.

Research question

What are the practice patterns and comparative effectiveness for inhaled nitric oxide and epoprostenol in severe ARF?

Study design and methods

Using a large US database (Premier Healthcare Database), we identified adult patients with ARF or ARDS who were mechanically ventilated and started on inhaled nitric oxide, epoprostenol, or both. Leveraging large hospital variation in the choice of initial inhaled vasodilator, we compared the effectiveness of inhaled nitric oxide with that of

SUBMITTER: Bosch NA 

PROVIDER: S-EPMC9899639 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature