Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men.

ABSTRACT:

Background

Sleep is fragmented by brief arousals, and excessive arousal burden has been linked to increased cardiovascular (CV) risk, but mechanisms are poorly understood.

Research question

Do arousals trigger cardiac ventricular repolarization lability that may predispose people to long-term cardiovascular mortality?

Study design and methods

This study analyzed 407,541 arousals in the overnight polysomnograms of 2,558 older men in the Osteoporotic Fractures in Men sleep study. QT and RR intervals were measured beat-to-beat starting 15 s prior to arousal onset until 15 s past onset. Ventricular repolarization lability was quantified by using the QT variability index (QTVi).

Results

During 10.1 ± 2.5 years of follow-up, 1,000 men died of any cause, including 348

SUBMITTER: Shahrbabaki SS 

PROVIDER: S-EPMC9899642 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature