Mercury chloride alters heterochromatin domain organization and nucleolar activity in mouse liver.

ABSTRACT: Mercury is a highly toxic element that induces severe alterations and a broad range of adverse effects on health. Its exposure is a global concern because it is widespread in the environment due to its multiple industrial, domestic, agricultural and medical usages. Among its various chemical forms, both humans and animals are mainly exposed to mercury chloride (HgCl₂), methylmercury and elemental mercury. HgCl₂ is metabolized primarily in the liver. We analysed the effects on the nuclear architecture of an increasing dosage of HgCl₂ in mouse hepatocytes cell culture and in mouse liver, focusing specifically on the organization, on some epigenetic features of the heterochromatin domains and on the nucleolar morphology and activity. Through the combination of

SUBMITTER: Zannino L 

PROVIDER: S-EPMC9899742 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature