Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.

ABSTRACT: Macrophages are important players in the maintenance of tissue homeostasis¹. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma², and their role in CNS physiology has not been sufficiently well studied. Given their continuous interaction with the cerebrospinal fluid (CSF) and strategic positioning, we refer to these cells collectively as parenchymal border macrophages (PBMs). Here we demonstrate that PBMs regulate CSF flow dynamics. We identify a subpopulation of PBMs that express high levels of CD163 and LYVE1 (scavenger receptor proteins), closely associated with the brain arterial tree, and show that LYVE1⁺ PBMs regulate arterial motion that drives CSF flow. Pharmacological or genetic depletion of PBMs led

SUBMITTER: Drieu A 

PROVIDER: S-EPMC9899827 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature