HPAI-resistant Ri chickens exhibit elevated antiviral immune-related gene expression.

ABSTRACT:

Background

Highly pathogenic avian influenza viruses (HPAIVs) is an extremely contagious and high mortality rates in chickens resulting in substantial economic impact on the poultry sector. Therefore, it is necessary to elucidate the pathogenic mechanism of HPAIV for infection control.

Objective

Gene set enrichment analysis (GSEA) can effectively avoid the limitations of subjective screening for differential gene expression. Therefore, we performed GSEA to compare HPAI-infected resistant and susceptible Ri chicken lines.

Methods

The Ri chickens Mx(A)/BF2(B21) were chosen as resistant, and the chickens Mx(G)/BF2(B13) were selected as susceptible by genotyping the Mx and BF2 genes. The tracheal tissues of HPAIV H5N1 infected chickens were col

SUBMITTER: Vu TH 

PROVIDER: S-EPMC9899939 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature