Comparative study on the effects of micro- and nano-sized zinc oxide supplementation on zinc-deficient mice.

ABSTRACT:

Background

Zinc (Zn) is an essential cofactor for physiological homeostasis in the body. Zn oxide (ZnO), an inorganic compound that supplies Zn, exists in various sizes, and its bioavailability may vary depending on the size in vivo. However, comparative studies on the nutritional effects of micro-sized ZnO (M-ZnO) and nano-sized ZnO (N-ZnO) supplementation on Zn deficiency (ZnD) animal models have not been reported.

Objectives

This study investigated the nutritional bioavailability of N-ZnO and M-ZnO particles in dietary-induced ZnD mice.

Methods

Animals were divided into six experimental groups: normal group, ZnD control group, and four ZnO treatment groups (Nano-Low, Nano-High, Micro-Low, and Micro-High). After ZnD induction, N-ZnO or M-ZnO was administered

SUBMITTER: Yoon JS 

PROVIDER: S-EPMC9899942 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature