Pharmacokinetics and biosafety evaluation of a veterinary drug florfenicol in rainbow trout, Oncorhynchus mykiss (Walbaum 1792) as a model cultivable fish species in temperate water.

ABSTRACT: In two experimental trials; florfenicol pharmacokinetics following a single dose oral administration at 15 mg kg^-1 fish body weight and biosafety through extended medicated feeding were studied in the rainbow trout, Oncorhynchus mykiss. The pharmacokinetic trial was conducted for 5 days, whereas the biosafety experiment lasted for a 30-day safety margin followed by a 20-day residual period analysis at 3, 5 and 10 times greater than the therapeutic dose 10 mg kg^-1 biomass day^-1. C _max µg kg^-1 calculated for florfenicol were found to be 5,360 in intestine, 2,890 in gill, 2,250 in kidney, 973 in liver and 273 in plasma, obtained at T _max of 16 h. Intestine had utmost area under the concentration-time curve

SUBMITTER: Mallik SK 

PROVIDER: S-EPMC9900004 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature