MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma.

ABSTRACT:

Background

High expression of matrix metalloproteinase-11 (MMP11) is associated with various tumors and immune microenvironments. Conversely, poor response to immunotherapy in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients is closely related to the characteristics of immune microenvironment.

Methods

The Cancer Genome Atlas (TCGA)-LUAD database and our gathered clinical LUAD samples were used to examine the relationship between MMP11 expression and EGFR mutation. Then the correlation between MMP11 and immune response and the difference of immune cell infiltration in different groups were analyzed. Compared the differences in the immune microenvironment between the MMP11-positive and MMP11-negative expression groups using immunohistochemistr

SUBMITTER: Bai L 

PROVIDER: S-EPMC9900007 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature