Benefits of high-dose intravenous immunoglobulin on mortality in patients with severe COVID-19: An updated systematic review and meta-analysis.

ABSTRACT:

Background

The clinical benefits of high-dose intravenous immunoglobulin (IVIg) in treating COVID-19 remained controversial.

Methods

We systematically searched databases up to February 17, 2022, for studies examining the efficacy of IVIg compared to routine care. Meta-analyses were conducted using the random-effects model. Subgroup analysis, meta-regression, and trial series analysis w ere performed to explore heterogeneity and statistical significance.

Results

A total of 4,711 hospitalized COVID-19 patients (1,925 IVIg treated and 2786 control) were collected from 17 studies, including five randomized controlled trials (RCTs) and 12 cohort studies. The application of IVIg was not associated with all-cause mortality (RR= 0.89 [0.63, 1.26], P= 0.53; I² = 75%

SUBMITTER: Liu X 

PROVIDER: S-EPMC9900022 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature