FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate.

ABSTRACT:

Objectives

Normal saline (NS) and Ringer's lactate (RL) are the most common crystalloids used for fluid therapy. Despite evidence of possible harm associated with NS (eg, hyperchloremic metabolic acidosis, impaired kidney function and death), few large multi-centre randomised trials have evaluated the effect of these fluids on clinically important outcomes. We conducted a pilot trial to explore the feasibility of a large trial powered for clinically important outcomes.

Design

FLUID was a pragmatic pilot cluster randomised cross-over trial.

Setting

Four hospitals in the province of Ontario, Canada PARTICIPANTS: All hospitalised adult and paediatric patients with an incident admission to the hospital over the course of each study period.

Interventions

A hospital

SUBMITTER: McIntyre LA 

PROVIDER: S-EPMC9900065 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature