Sodium channel-inhibiting drugs and cancer-specific survival: a population-based study of electronic primary care data.

ABSTRACT:

Objectives

Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na⁺) channels (VGSCs), and preclinical studies show that these medications reduce tumour growth, invasion and metastasis. We investigated the association between VGSC inhibitor use and survival in patients with breast, bowel and prostate cancer.

Design

Retrospective cohort study.

Setting

Individual electronic primary healthcare records extracted from the Clinical Practice Research Datalink.

Participants

Records for 132 996 patients with a diagnosis of breast, bowel or prostate cancer.

Outcome measures

Adjusted Cox proportional hazards regression was used to analyse cancer-specific survival associated with exposure to VGSC inhibitors. Exposure to non-VGSC-inhibiting

SUBMITTER: Fairhurst C 

PROVIDER: S-EPMC9900071 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature