A connection between survival multistate models and causal inference for external treatment interruptions.

ABSTRACT: Recently, treatment interruptions such as a clinical hold in randomized clinical trials have been investigated by using a multistate model approach. The phase III clinical trial START (Stimulating Targeted Antigenic Response To non-small-cell cancer) with primary endpoint overall survival was temporarily placed on hold for enrollment and treatment by the US Food and Drug Administration (FDA). Multistate models provide a flexible framework to account for treatment interruptions induced by a time-dependent external covariate. Extending previous work, we propose a censoring and a filtering approach both aimed at estimating the initial treatment effect on overall survival in the hypothetical situation of no clinical hold. A special focus is on creating a link to causal inference. We show that

SUBMITTER: Erdmann A 

PROVIDER: S-EPMC9900139 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature