Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli.

ABSTRACT:

Introduction

Neutrophils represent the largest proportion of circulating leukocytes and, in response to inflammatory stimuli, are rapidly recruited to sites of infection where they neutralize pathogens.

Methods and results

We have identified a novel neutrophil transcription network induced in response to inflammatory stimuli. We performed the first RNAseq analysis of human neutrophils exposed to lipopolysaccharide (LPS), followed by a meta-analysis of our dataset and previously published studies of LPS-challenged neutrophils. This revealed a robustly enhanced transcriptional network driven by forkhead box (FOX) transcription factors. The network is enriched in genes encoding proinflammatory cytokines and transcription factors, including MAFF and ATF3, which are implicated in

SUBMITTER: Ismailova A 

PROVIDER: S-EPMC9900176 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature