Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer.

ABSTRACT: Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficacy. The landscape of the TME differs substantially across PDAC subtypes, indicating context-specific principles of immunosuppression. In this review, we discuss how PDAC cells, the local TME, and systemic host and environmental factors drive immunosuppression in context. We argue that unraveling the mechanistic drivers of the context-specific modes of immunosuppression will open new possibilities to target PDAC more efficiently by using multimodal (immuno)therapeutic interventions.

Significance

Immunosuppression is an almost universal hal

SUBMITTER: Falcomata C 

PROVIDER: S-EPMC9900325 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature