Rates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL ¹⁸F-MK6240 PET study.

ABSTRACT:

Background

Tau positron emission tomography (PET) imaging enables longitudinal observation of tau accumulation in Alzheimer's disease (AD). ¹⁸F-MK6240 is a high affinity tracer for the paired helical filaments of tau in AD, widely used in clinical trials, despite sparse longitudinal natural history data. We aimed to evaluate the natural history of tau accumulation, and the impact of disease stage and reference region on the magnitude and effect size of regional change.

Methods

One hundred and eighty-four participants: 89 cognitively unimpaired (CU) beta-amyloid negative (Aβ-), 44 CU Aβ+, 51 cognitively impaired Aβ+ (26 with mild cognitive impairment [MCI] and 25 with dementia) had follow-up ¹⁸F-MK6240 PET for one to four years (median 1.48). Regional st

SUBMITTER: Krishnadas N 

PROVIDER: S-EPMC9900352 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature