A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice.

ABSTRACT:

Objectives

Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease that can range from hepatic steatosis to non-alcoholic steatohepatitis (NASH), which can lead to fibrosis and cirrhosis. Recently, ketogenic diet (KD), a low carbohydrate diet, gained popularity as a weight-loss approach, although it has been reported to induce hepatic insulin resistance and steatosis in animal model systems via an undefined mechanism. Herein, we investigated the KD metabolic benefits and its contribution to the pathogenesis of NASH.

Methods

Using metabolic, biochemical and omics approaches, we identified the effects of a KD on NASH and investigated the mechanisms by which KD induces hepatic insulin resistance and steatosis.

Results

We demonstrate that

SUBMITTER: Long F 

PROVIDER: S-EPMC9900440 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature