Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease.

ABSTRACT: The excessive reactive oxygen species (ROS) is a hallmark associated with the initiation and progression of inflammatory bowel disease (IBD), which execrably form a vicious cycle of ROS and inflammation to continually promote disease progression. Here, the gold nanoparticles-embedded ceria nanoparticles (Au/CeO₂) with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced ROS. The Au/CeO₂ with core-shell and porous structure exhibits significantly higher enzymatic catalytic activities compared with commercial ceria nanoparticles, likely due to the effective exposure of catalytic sites, higher content of Ce (III) and oxygen vacancy, and accelerated reduction from Ce (IV) to Ce (III). Being coated with negat

SUBMITTER: Li M 

PROVIDER: S-EPMC9900456 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature