Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.

ABSTRACT:

Objectives

To address whether sparing the medial retropharyngeal lymph node (MRLN) region from elective irradiation volume provides non-inferior local relapse-free survival versus standard radiotherapy in patients with nasopharyngeal carcinoma.

Design

Open-label, non-inferiority, multicentre, randomised, phase 3 trial.

Setting

Three Chinese hospitals between 20 November 2017 and 3 December 2018.

Participants

Adults (18-65 years) with newly diagnosed, non-keratinising, non-distant metastatic nasopharyngeal carcinoma without MRLN involvement.

Interventions

Randomisation was done centrally by the Clinical Trials Centre at Sun Yat-sen University Cancer Center. Eligible patients were randomly assigned (1:1; block size of four) to receive MRLN sparing radiothe

SUBMITTER: Mao YP 

PROVIDER: S-EPMC9900470 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature